Everything about Farnesyl Pyrophosphate totally explained
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Farnesyl pyrophosphate (FPP) is an intermediate in the
HMG-CoA reductase pathway used by organisms in the biosynthesis of
terpenes and
terpenoids.
It is the immediate precursor of
squalene (via the enzyme
squalene synthase), dehydrodolichol diphosphate (a precursor of
dolichol), and geranylgeranyl pyrophoshate (GGPP).
Biosynthesis
Farnesyl pyrophosphate synthase (a
prenyl transferase) catalyzes sequential condensation reactions of
dimethylallyl pyrophosphate with 2 units of 3-isopentenyl pyrophosphate to form farnesyl pyrophosphate.
Geranyl pyrophosphate itself reacts with 3-isopentenyl pyrophosphate to form farnesyl pyrophosphate
Regulation
The above reactions are inhibited by bisphosphonates (used for osteoporosis).
Related compounds
Farnesene
Farnesol
Further Information
Get more info on 'Farnesyl Pyrophosphate'.
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